Karl Landsteiner and the Discovery of the Major Blood Types

Karl Landsteiner and the Discovery of the Major Blood Types Austrian physician and immunologist Karl Landsteiner (June 14, 1868 - June 26, 1943) is most noted for his discovery of the major blood types and developing a system for blood typing. This discovery made it possible to determine blood compatibility for safe blood transfusions. Fast Facts: Karl Landsteiner Born: June 14, 1868, in Vienna, AustriaDied: June 26, 1943, in New York, New YorkParents Names: Leopold and Fanny Hess LandsteinerSpouse: Helen Wlasto (m. 1916)Child: Ernst Karl LandsteinerEducation: University of Vienna (M.D.)Key Accomplishments: Nobel Prize for Physiology or Medicine (1930) Early Years Karl Landsteiner was born in Vienna, Austria in 1868, to Fanny and Leopold Landsteiner. His father was a popular journalist and Viennese newspaper publisher and editor. The death of Karls father, when he was only six years of age, resulted in the development of an even closer relationship between Karl and his mother. Young Karl was always interested in science and mathematics and was an honor student during his primary and secondary school years. In 1885, he began studying medicine at the University of Vienna and earned an M.D. in 1891. While at the University of Vienna, Landsteiner became very interested in blood chemistry. Upon earning his M.D., he spent the next five years doing biochemical research in laboratories of well known European scientists, one of whom was Emil Fischer, an organic chemist who won a Nobel Prize in Chemistry (1902) for his research on carbohydrates, specifically sugars. Career and Research Dr. Landsteiner returned to Vienna in 1896 to continue to study medicine at Vienna General Hospital. He became an assistant to Max von Gruber at the Hygiene Institute, where he studied antibodies and immunity. Von Gruber had developed a blood test to identify the bacteria responsible for typhoid and contended that chemical signals on the bacteria were being recognized by antibodies in the blood. Landsteiners interest in antibody studies and immunology continued to develop as a result of working with Von Gruber. In 1898, Landsteiner became assistant to Anton Weichselbaum at the Institute of Pathological Anatomy. For the next ten years, he conducted research in the areas of serology, microbiology, and anatomy. During this time, Landsteiner made his famous discovery of blood groups and developed a system for classifying human blood. Discovery of the Blood Groups Dr. Landsteiners investigations of interactions between red blood cells (RBCs) and serum of different people were initially noted in 1900. He observed the agglutination, or clumping together, of red blood cells when mixed with animal blood or other human blood. While Landsteiner was not the first to make these observations, he is credited with being the first to explain the biological processes behind the reaction. Landsteiner performed experiments testing red blood cells against serum from the same patient as well as serum from different patients. He noted that a patients RBCs did not agglutinate in the presence of their own serum. He also identified different patterns of reactivity and categorized them into three groups: A, B, and C. Landsteiner observed that when the RBCs from group A were mixed with serum from group B, the cells in group A clumped together. The same was true when RBCs from group B were mixed with serum from group A. The blood cells of group C did not react to serum from either groups A or B. However, the serum from group C caused agglutination in RBCs from both groups A and B. This image shows agglutination (clumping) of type A red blood cells when mixed with ANTI-A serum. No clumping occurs when mixed with ANTI-B serum.   Ed Reschke/Photolibrary/Getty Images Landsteiner determined that blood groups A and B have different types of agglutinogens, or antigens, on the surface of their red blood cells. They also have different antibodies (anti-A, anti-B) present in their blood serum. A student of Landsteiners later identified an AB blood group that reacted with both A and B antibodies. Landsteiners discovery became the basis for the ABO blood grouping system (as the name of group C was later changed to type O). Landsteiners work laid the foundation for our understanding of blood groupings. Cells from blood type A have A antigens on the cell surfaces and B antibodies in the serum, while cells from type B have B antigens on the cell surfaces and A antibodies in the serum. When type A RBCs contact serum from type B, A antibodies present in B serum bind to A antigens on the blood cell surfaces. This binding causes the cells to clump together. Antibodies in the serum identify the blood cells as foreign and initiate an immune response to neutralize the threat. A similar reaction occurs when type B RBCs contact serum from type A containing B antibodies. Blood type O has no antigens on the blood cell surfaces and do not react with serum from either types A or B. Blood type O does have both A and B antibodies in the serum and thus reacts with RBCs from both A and B groups. Landsteiners work made blood typing possible for safe blood transfusions. His findings were published in the Central European Journal of Medicine, Wiener klinische Wochenschrift, in 1901. He received the Nobel Prize for Physiology or Medicine (1930) for this life saving accomplishment. In 1923, Landsteiner made additional blood grouping discoveries while working in New York at the Rockefeller Institute for Medical Research. He helped to identify blood groups M, N, and P, which were initially used in paternity testing. In 1940, Landsteiner and Alexander Wiener discovered the Rh factor blood group, named for research conducted with rhesus monkeys. The presence of the Rh factor on blood cells indicates an Rh positive (Rh) type. The absence of the Rh factor indicates an Rh negative (Rh-) type. This discovery provided a means for Rh blood type matching to prevent incompatibility reactions during transfusions.   Death and Legacy   Karl Landsteiners contribution to medicine extended beyond blood groupings. In 1906, he developed a technique for the identification of the bacterium (T. pallidum) that causes syphilis using dark-field microscopy. His work with poliomyelitis (polio virus) lead to the discovery of its mechanism of action and development of a diagnostic blood test for the virus. In addition, Landsteiners research on small molecules called haptens helped to elucidate their involvement in the immune response and the production of antibodies. These molecules ramp up immune responses to antigens and induce hypersensitivity reactions. Landsteiner continued researching blood groups after retiring from the Rockefeller Institute in 1939. He would later change his focus to the study of malignant tumors in an attempt to find a cure for his wife, Helen Wlasto (m. 1916), who was diagnosed with thyroid cancer. Karl Landsteiner suffered a heart attack while in his laboratory and died a couple of days later on June 26, 1943. Sources Durand, Joel K., and Monte S. Willis. Karl Landsteiner, MD: Transfusion Medicine. Laboratory Medicine, vol. 41, no. 1, 2010, pp. 53–55., doi:10.1309/lm0miclh4gg3qndc.  Erkes, Dan A., and Senthamil R. Selvan. Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity. Journal of Immunology Research, vol. 2014, 2014, pp. 1–28., doi:10.1155/2014/175265.  Karl Landsteiner – Biographical. Nobelprize.org, Nobel Media AB, www.nobelprize.org/prizes/medicine/1930/landsteiner/biographical/.

The Answer to Petals Around the Rose Is ...

The Answer to Petals Around the Rose Is ... Petals Around the Rose is a puzzle game you play with dice and a friend who already knows how to play. The challenge is to answer the question how many petals are around the rose following each roll of the dice. The new player must use inductive reasoning to figure out what the rose is, what the petals are, and how to answer the question posed by the name of the game. How to Play Petals Around the Rose You need five dice (or more, if you want a harder game). They should be traditional dice with from one to six spots on each side. The player who already knows the answer to the game tosses the dice, looks at them and then tells the new player how many petals are around the rose, without revealing the logic behind the answer. The new player then tosses the dice. The player who knows the answer to the puzzle states how many petals there are around the rose of the new players toss without explaining how he arrived at the answer. The players continue to take turns tossing the dice. The player who knows the answer to the game states the number of petals around the rose of both his and the new players tosses, after giving the new player a chance to study his toss and figure out an answer. Eventually, the new player should figure out the secret and give the correct response. Just to confirm the player has solved the puzzle (and didnt make a lucky guess), he tosses the dice a few more times and states the correct answer each time. The Secret to Playing Petals Around the Rose When the dice are rolled, they come to rest with a single side facing upward. The rose is the dot in the center of an upward facing die side. The dice that show a one, three  and five sides each have a rose; the sides with two, four or six dots do not have a dot in the center of the die, so they do not have a rose. The petals are the dots that appear around the center dot (the rose). The one die doesnt have any petals because it doesnt have any dots other than the rose in the center. The two, four and six dies dont have any petals because they dont have a center rose. The three die has two petals around the center rose, while the five die has four petals around the center rose. On each toss of the dice, you need to look only at the dice that display a three and a five. They are the only numbers with both a rose and petals. Count the spots that are not in the center- two on a three die and four on a five die- and speak the total. That is the secret to playing the game.

Organization Behaviour and Leadership Development Scenarios Essay

Organization Behaviour and Leadership Development Scenarios - Essay Example Scenario two setting involved unifying two competing junior employees i.e. Rosa and oli by finding common and unifying ideas, hence unifying them is of great importance in meeting the company objectives. The objective of this scenario was to get oli and Rosa to agree on maintaining customer retention in the call center at 65 % and also getting everyone to agree on using automated phone system. The steps I took to resolve this scenario were, actively listening to oli and Rosa, encouraging oli and Rosa to communicate to help reach an effective agreement, through asserting my leadership power toward ending the squabbles between them. Using work strategies tactics of constantly reminding them the goal of the organization in addition to using tension strategies where I introduced relaxing ideas that aimed to eliminate tension created by oli and Rosa The key learning point that emerged from this scenario was that tension in at workplace can lead to little work being accomplished, it is of great paramount to stay neutral where employee friction is involved in order to help them out, through focusing on goals of organization and constant reminder help people to work harmoniously, effective communication within organization facilitate dialogue that helps to resolve dialogue between employees and creating a kind of numeration system that helps employers to cooperate and work together.Supporting theory and academic insight for this scenario can be derived from democratic leadership.... ning to oli and Rosa, encouraging oli and Rosa to communicate to help reach an effective agreement, through asserting my leadership power toward ending the squabbles between them. Using work strategies tactics of constantly reminding them the goal of the organization in addition of using tension strategies where I introduced relaxing ideas that aimed to eliminate tension created by oli and Rosa The key learning point that emerged from this scenario was that tension in at work place can lead to little work being accomplished, it is of great paramount to stay neutral where employee friction is involved in order to help them out, through focusing on goals of organization and constant reminder help people to work harmoniously, effective communication within organization facilitate dialogue that help to resolve dialogue between employees and creating a kind of numeration system that help employee to cooperate and work together to achieve set goals in addition to engagement in team buildin g exercises. Supporting theory and academic insight for this scenario can be derive from democratic leadership , which is characterized by emphasizes in group participation , where decision and discussion are encouraged by leaders hence giving team member a voice in decision making (Goleman, 2000). Democratic leadership style builds flexibility and responsibility in an organization which in turn help in generating new ideas. . (Goleman, 2000).Through listening to team members in an organization which is encouraged by democratic leadership, leaders learn to resolve dispute between employees and in decision making. (Goleman, 2000). Third Scenario The third scenario set up was learning to manage up, where it is critical important for a leader to mange his juniors but at the same time have

To Build a Fire by Jack London why did the traveler die If you know of Essay

To Build a Fire by Jack London why did the traveler die If you know of a personal application for the life lesson shown in this story, you may briefly inclu - Essay Example The man’s errors of judgment leads to his death, whereas the only way out of it would have been to show respect to the advice by experienced people, to the laws of the nature, and to his own natural instincts instead of relying too much on artificial means of survival. London employs a strict and effective economy of words and terse plot construction to produce a powerful story replete with multiple layers of meaning. Though the unpredictable aspects of Nature play a major part in the devastation of the protagonist, the presence of a wild dog that accompanies him on his journey brings in many contrasts. The most significant among them is between the man’s estrangement from his own instincts that causes his death and the uninformed yet natural instincts of the beast that helps it survive. The characterization of the man is done deftly through references to his attitude to the excruciating cold which he understands to be fifty degrees below zero, but is in fact seventy five below zero. London describes that the absence of the sun or the tremendous cold did not make an impression on the man. It is not because he was used to it, as he is a newcomer to the place and it was his first winter. â€Å"The trouble with him was that he was without imagination† (London). He understands the extreme cold temperature on practical terms only, and tries to deal with it logically, taking for granted the man-made equipments which he hopes will protect him from the powers of Nature. The information that the temperature is in fact much below what the man understood it to be is sufficient to prepare the readers for his death. His inexperience in the terrain and his ruthlessness in discarding good advice are also explained from the beginning. However, readers are apt to hope against hope for the man’s survival, as he is depicted as giving a hearty fight till the end. The natural

Realism Naturalism English

Realism Naturalism English Realism and Naturalism are two similar literary movements of the 19th and 20th century that deal with the real, cruel world. Realism was developed in the early 1800s as a branch off of Romanticism which also dealt with ordinary, â€Å"natural† life. Realism most straightforwardly is â€Å"the truthful treatment of material.† Writers in this movement focused mainly on everyday, natural incidents involving ordinary people, nothing too extreme or out of the ordinary. This movement put most emphasis on detached, precise observations of human life. Some such writers were Mark Twain and Dean Howells. Naturalism was just a more extreme, darker version of Realism. However Naturalism is based on very different philosophy in which people are prisoners of their inheritance and social environment, a result of Darwinian influence of scientific reasoning. In Naturalism, life is viewed more as machine like than humanistic; man is simply just another animal on planet earth driven by hi s chemistry and environment. Spirituality has no part in this literary movement; it is all scientifically based. A few writers in this movement were Theodore Dreiser and Ambrose Beirce. Although Realism and Naturalism are quite similar movements, they are still two very distinct philosophical views on life as illustrated in two pieces of such literature: â€Å"Hedda Gabler† by Henrik Isben and â€Å"Chickamauga† written by Ambrose Beirce. â€Å"Hedda Gabler† is a play written in 1890 by Henrik Ibsen, a Realistic writer, in which Realism is displayed and its principles qualified. Since Realism is a movement dedicated to revealing the vulgarity and cruelty of society to the people this story is likewise an account of a perverse, earthy society. It is based and names after the main character, Hedda Gabler. Gabler is her maiden name, but using it as the title sets the Realistic tone that all she ever did was care for herself and her formerly comfortable, aristocratic lifestyle. She is a prime example of how perverse society and its morality really is. Hedda was married to George Tesman and apparently pregnant with his child which morally is supposed to mean that she has some sort of binding love with him, however, she confessed to Mrs. Elvsted that even after all that, she really had no true feelings for Tesman. Not only does she not love her husband but she has no problem with cheating on him with his scholarly ar chrival, Eilert Loevborg. This is a prime illustration of the Realistic view of a perverse society. Although this story is pointing out the perverse nature of mankind, it is not taking and humane traits out of the characters like Naturalism; it is a much less extreme example of an ultimately corrupt humanity. â€Å"Chickamauga† is a short story written by American Ambrose Beirce, a sardonic author obsessed with death, a Naturalism characteristic, which can blatantly be seen in this story. Naturalism comes from a desire to shock the middle class with thorough and vivid depictions of sadistic, animalistic characters. First of all, Beirces attitude towards the six year old boy in the story, referring to the boy as â€Å"it†, qualifies the Naturalistic principle that man is merely just another animal, no more than a lab case study. Naturalists do not believe than humans possess any kind of otherworldly soul that separates them from all other life forms. This is portrayed especially by the boy and also somewhat by the soldiers and other characters in the story. Already has Beirce started dehumanizing the boy by calling him â€Å"it†, but also they way he writes about him in such an annoyed, insufferable manor it is plain to see that to the Naturalists, the boy is worthless . It is even more appalling considering the inconsiderate tone Beirce took with the boy to find out at the end that he was a deaf mute. Naturalists have no more care for poor children with handicaps than they do with anything else. This detached tone is also taken with the maimed, dying soldiers dragging themselves to the creek. They are plainly observed by the young boy who was amused and intrigued, not aghast, by the awkward way their maimed bodies approached the creek and by how the men whod let their heads down to get a drink had been too weak to lift their heads back out and had drowned in the water. Realists do not take the human factor out of mankind like Naturalists do; they simply observe without any kind of emotion or attachment to the characters and setting. Not only are these soldiers being described and treated inhumanly, the childs reaction to these images were solely influenced and determined by his past experiences, his environment. These men were suffering incredibly and the young boy just laughed as he saw them approaching and thought nothing of their disfigured features until one of them aggressively pushed him off of his back onto the ground. At first he thought of them as amusing because the red blood that covered their faces and bodies reminded him of a clown he had once been entertained by, and the way some of them were crawling reminded him of the way some of his familys slaves had pretended to be horses for him to ride. Because of his past experiences with seemingly similar circumstances, the boy was not afraid and even jumped on the back of one of the crawling soldiers he thought was also pretending to be a horse. However, after the man shoved the little boy off onto the ground and the boy saw his disfigured face he finall y became afraid. The mans jawless, bloody face reminded the little boy of a carnivorous bird after its kill. Both of these reactions were not based on any kind of feeling; they were simply reactions to the boys environment, another principle of Naturalism. Realism does not try to give any reasons for a characters actions whether they are results of their environment or moral responsibilities. Naturalism is a scientific philosophy rationalizing how and why man works the way he does; Realism simply tries to put an accurate emphasis on humane understanding, leaving the characters motive to himself. Although Realism and Naturalism do branch off from each other, they are very different in that Realism leaves the humanistic qualities and just focusing on true observations of a corrupt society whereas Naturalism is a scientific philosophy that mankind is nothing more than another life form on earth acting upon only his chemistry and environmental circumstances. â€Å"Hedda Gabler† and â€Å"Chickamauga† were two very suitable examples of each literary movement. They both clearly exhibited the principles of each movement to the reader.

Objective And Impressionistic Description

Objective and Impressionistic DescriptionThere are two ways to describe depending on the kind of result or response that you like to elicit from the reader. Objective description is the enumeration of details in a matter-of-fact way to simply show the appearance or condition of a person, place,or thing. This kind of description is commonly used when writing journalistic,reports,encyclopedia entries,or scientific observations. Impressionistic description is used when you like to imply certain feelings, or set a mood, or build an atmosphere in what is described. The use of highly connotative words and abstraction usually results in more impressionistic descriptions. This kind of description is often found in literary works and feature articles.Consider this objective description of an eagle:An eagle is any of the hawk family, Accipitridae. Eagles have hooked beaks,curved claws (called talons), keen eyesight, powerful wings, strong bodies, and feathered legs. Land eagles build their nes ts high up in trees,while sea eagles (or ernes) usually build theirs on the rocky ledges of cliffs. Eagles feed on small mammals,birds,fish, and carreon.Now take a look at this impressionistic description of â€Å"The Eagle† by Alfred Lord Tennyson: He clasps the crag with crooked hands; Close to the sun in lonely lands. Ringed with the azure world, he stands.The wrinkled sea beneath him crawls; He watches from his mountain walls, And like a thunderbolt, he falls.Objective and Impressionistic DescriptionThere are two ways to describe depending on the kind of result or response that you like to elicit from the reader. Objective description is the enumeration of details in a matter-of-fact way to simply show the appearance or condition of a person, place,or thing. This kind of description is commonly used when writing journalistic,reports,encyclopedia entries,or scientific observations. Impressionistic description is used when you like  to imply certain feelings, or set a moo d, or build an atmosphere in what is described. The use of highly connotative words and abstraction usually results in more impressionistic descriptions. This kind of description is often found in literary works and feature articles.Consider this objective description of an eagle:An eagle is any of the hawk family, Accipitridae. Eagles have hooked beaks,curved claws (called talons), keen eyesight, powerful wings, strong bodies, and feathered legs. Land eagles build their nests high up in trees,while sea eagles (or ernes) usually build theirs on the rocky ledges of cliffs. Eagles feed on small mammals,birds,fish, and carreon.Now take a look at this impressionistic description of â€Å"The Eagle† by Alfred Lord Tennyson: He clasps the crag with crooked hands; Close to the sun in lonely lands. Ringed with the azure world, he stands.The wrinkled sea beneath him crawls; He watches from his mountain walls, And like a thunderbolt, he falls.Objective and Impressionistic DescriptionTh ere are two ways to describe depending on the kind of result or response that you like to elicit from the reader. Objective description is the enumeration of details in a matter-of-fact way to simply show the appearance or condition of a person, place,or thing. This kind of description is commonly used when writing journalistic,reports,encyclopedia entries,or scientific observations. Impressionistic description is used when you like to imply certain feelings, or set a mood, or build an atmosphere in what is described. The use of highly connotative words and abstraction usually results in more impressionistic descriptions. This kind of description is often found in literary works and feature articles.Consider this objective description of an eagle:An eagle is any of the hawk family,Accipitridae. Eagles have hooked  beaks,curved claws (called talons), keen eyesight, powerful wings, strong bodies, and feathered legs. Land eagles build their nests high up in trees,while sea eagles (or ernes) usually build theirs on the rocky ledges of cliffs. Eagles feed on small mammals,birds,fish, and carreon.Now take a look at this impressionistic description of â€Å"The Eagle† by Alfred Lord Tennyson: He clasps the crag with crooked hands; Close to the sun in lonely lands. Ringed with the azure world, he stands.The wrinkled sea beneath him crawls; He watches from his mountain walls, And like a thunderbolt, he falls.

Nike s Recent `` Equality Campaign `` Commercial Of A...

This essay seeks to analyze Nike’s recent â€Å"equality campaign† commercial that was released in February 2017. Nike, the American sports brand giant who makes up 31% of the athletic footwear market (Keady, 2011), has been noted for creating political statements alongside the consumer goods that they produce. As seen in the short black and white filmed advertisement, famous American athletes Lebron James, Megan Rapinoe, Kevin Durant, and Serena Williams are depicted standing up against social inequalities experienced by racial minorities and other marginalized groups; other marginalized groups include those such as the LGBT community as represented by soccer star Megan Rapinoe. The basic idea behind the piece is to illustrate that if equality†¦show more content†¦As seen with the Nike â€Å"equality campaign† commercial, Nike is calling for those who buy their products to almost break through the current social boundaries and to move â€Å"past these lines.† The quote of moving â€Å"past these lines† aids in furthering the post-Fordist concept of uniqueness as it almost encourages one to think outside the box and to be different by going against societal limitations and norms while in hopes of striving for equality; it gives a sense of inspiration to those who witness the commercial. Nike is commanding for not only their consumer base, but all those who view this ad to be active in fighting for equality for all races and other minority groups. Nike believes this idea starts with â€Å"you,† and not by those who are atop the social hierarchy like those in governmental positions; taking a bottom to top approach. 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